Hemispheric supratentorial glioblastoma of granular cells. Case presentation and literature review
Keywords:
astrocitoma de células granulares, glioblastoma multicéntrico, nimotuzumab, racotumomab, tratamiento multimodal.Abstract
A 52-year-old man was referred to our hospital for the appearance of generalized epileptic seizures with loss of consciousness, and a computed tomography scan reveals multiple contrast-enhanced hemispheric supratentorial lesions, considering a multicentric Glioblastoma. A stereotactic biopsy was performed and abundant large cells with compact eosinophilic granular cytoplasm were found in the specimen, positive for gliofibrillar acid protein, S100 protein and CD68, focally, with scarce neoplastic astrocytes. Final diagnosis was granular cell astrocytoma. Multimodal treatment with radiotherapy, chemotherapy and immunotherapy was established. He remained at Karnofsky Performance Score (KPS) 80 during the first year and then, with tumor progression, a stability of KPS 50 for 6 months until he died 21 months after diagnosis. The bibliographic review carried out showed, to date, 104 diagnosed hemispheric supratentorial granular cell astrocytomas, with a survival of less than one year, regardless of the degree of malignancy. Multimodal treatment is recommended for these types of aggressive behavioral brain tumor.
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