Estimation of Cole-Cole model parameters with multifrequency-bioelectrical impedance analysis in newly diagnosed lung cancer adult patients
Keywords:
multi-frequency bioelectrical impedance analysis; newly diagnosed lung cancer adult patients; Cole-Cole distribution function; intracellular and extracellular electrical resistance; characteristic frequencyAbstract
Introduction: The bioelectrical impedance analysis is used for the evaluation and monitoring in cancer patients.
Objective: To estimate whole bioelectrical parameters obtained from the Cole-Cole distribution function with multifrequency-bioelectrical impedance analysis in newly diagnosed lung cancer adult patients.
Methods: A pilot, prospective and cross-sectional study was carried out to measure the bioelectrical parameters with multi-frequency Bioelectrical Impedance Analysis (at 5, 50, 100 and 200 kHz) in 23 newly diagnosed lung cancer adult patients. The Cole-Cole distribution function was used to estimate electrical resistance, capacitive reactance and impedance modulus between 100 Hz and 10 GHz.
Results: Differences between the simulated and experimental data (electrical impedance modulus > 10 Ω) were observed in seven lung cancer patients at 100 and 200 kHz. Cole-Cole distribution function underestimated experimental data in the majority of these patients at 5; 50 and 100 kHz, not so at 200 kHz. The intracellular resistance was higher than extracellular resistance in all them, in contrast with physiology. Furthermore, the overall cellular capacitance of cellular membrane in each lung cancer patient increased respect to that in apparently healthy subjects.
Conclusions: The bioelectrical impedance analysis reveals anomalous behaviors of bioelectrical parameters in each newly diagnosed lung cancer adult patients for frequencies above characteristic frequency. These behaviors may be described by distribution functions Cole-Cole (for 0 < α < 1) or others.
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