SYSTEMS MOLECULAR NEUROSCIENCE: FOCUS ON POLYGLUTAMINE DISORDERS
Abstract
Systems biology offers a valuable alternative to the classic “oslerian” approach to disease, particularly in the case of polyglutamine disorders. Efforts have been made to clarify the ´disease-home´ of polyglutamine disorders, particularly of Huntington´s disease and several Spinocerebellar Ataxias, through transcriptomic, proteomic and bio-informatics studies. The epistemic issue of ´causality´ raised by these functional studies can be solved by genome-scale loss of function studies, although the integration of the large amounts of heterogeneous information generated by these studies remains a challenge. It is expected that the application of system biology approaches to polyglutamine disorders will led to a personalized medicine at the patient level and to the discovery of effective therapeutics.
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