Neural plasticity mechanisms involved in the spatial memory recovery by basolateral amygdala stimulation in fimbria-fornix lesioned animals

Authors

  • Daymara Mercerón Martínez Centro Internacional de Restauración Neurológica
  • William Almaguer Melian Centro Internacional de Restauración Neurológica
  • Jorge Bergado Rosado Centro Internacional de Restauración Neurológica

Keywords:

amygdala, neural plasticity, hippocampus, prefrontal cortex and functional recovery

Abstract

Introduction: Recently, we have obtained experimental evidence that electrical stimulation of amygdala 15 min after a spatial memory task can facilitate spatial learning in memory impaired animals with fimbria-fornix lesion. Objectives: to study the neural plasticity mechanisms involved in the functional recovery in the fimbria-fornix lesioned animals triggered by basolateral amygdala electrical stimulation.
Methods: Proteins and genes related to neural plasticity were measured in the hippocampus and prefrontal cortex of fimbria-fornix lesioned male rats after four days of training in the water maze and stimulation of the basolateral amygdala.
Results: We found that amygdala stimulation increases hippocampus BDNF (Brain Derivated Neurotrophic Factor) levels in the lesioned animals, suggesting that BDNF is one of the critical mechanisms that promote the spatial memory recovery. Also, we have demonstrated that plasticity-related-genes such as bdnf and arc are probably involved in the restoration of lost functions in fimbria-fornix lesioned animals with amygdala stimulation. Moreover, the amygdala stimulation increases transiently c-Fos protein expression in cells of dentate gyrus of the hippocampus and the prefrontal cortex. Furthermore, we have provided data showing that amygdala stimulation induces an increase in MAP-2 (Microtubule Associated Protein-2), which is an indicator of dendrite growth and also of GAP-43 (Growth Associated Protein-43), which is an indicator of axonal growth in the prefrontal cortex and hippocampus. Conclusions: Consequently, the amygdala stimulation is able to activate brain regions relevant to memory processes and activate all forms of neural plasticity, leading to neurological restoration.

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Published

2021-04-30

How to Cite

Mercerón Martínez, D., Almaguer Melian, W., & Bergado Rosado, J. (2021). Neural plasticity mechanisms involved in the spatial memory recovery by basolateral amygdala stimulation in fimbria-fornix lesioned animals. Anales De La Academia De Ciencias De Cuba, 11(2), e859. Retrieved from https://revistaccuba.sld.cu/index.php/revacc/article/view/859

Issue

Vol. 11 No. 2 (2021): mayo-agosto

Section

Biomedical sciences

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