Chitosan and its salts: national production, characterization and pharmaceutical applications

Authors

Keywords:

chitosan, chitosan salts, spray drying, emulsions, release

Abstract

Introduction: The exoskeletons of crustaceans are sources of highly versatile biopolymers and solid wastes that pollute the environment. Objectives: Establish technological processes on an industrial scale to obtain chitosan and its salts, for biomedical applications.
Methods: A mixing temperature of 80 ° C and a reaction temperature of 100 °C/15 double minutes were the best conditions for obtaining chitosan. Chitosan salts were obtained by the spray drying method, establishing an inlet temperature of 160 °C ± 5 °C and an outlet temperature of 100 °C ± 5 °C, from a solution of chitosan in acetic or lactic acid.
Results: The characterization confirmed the obtaining of chitosan with a degree of deacetylation greater than 70 % and an average molecular mass of 310,000 g/mol; as well as the formation of the salts of the biopolymer soluble in water. The homogeneity of the properties of the products in the scaled batches and the reproducibility of the established technological processes, under the conditions of the national industry, were demonstrated. The physical, chemical and microbiological stability of the biopolymer and its salts was verified for 24 months. Its emulsifying capacity was evaluated, achieving the stabilization of semisolid systems. The emulsified and water-soluble bases, using chitosan and chitosan acetate, showed adequate physical stability without interference in the release of the model drug, their application as stabilizing agents being demonstrated. Conclusions: three new raw materials of national production were obtained on an industrial scale with quality, to be used in the pharmaceutical industry.

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Author Biography

Mirna Fernández Cervera, Instituto de Farmacia y Alimentos. Universidad de La Habana

Departamento de Farmacia

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Published

2021-09-04

How to Cite

de la Paz Martín-Viaña, N., Fernández Cervera, M., García Peña, C. M., Pérez Ricardo, D., Nogueira Mendoza, A., Montes de Oca Porto, Y., … Palazón López, Z. C. (2021). Chitosan and its salts: national production, characterization and pharmaceutical applications. Anales De La Academia De Ciencias De Cuba, 11(3), e1058. Retrieved from https://revistaccuba.sld.cu/index.php/revacc/article/view/1058

Issue

Vol. 11 No. 3 (2021): septiembre-diciembre

Section

Technical Sciences

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