Effect anti fatigue of Moringa oleifera Lam. capsules in mice
Keywords:
anti-fatigue activity, fatigue, moringa, forced swimming test, rotarod testAbstract
Introduction: Moringa oleifera Lam, originally from India, is a plant that has both medicinal and nutritional use due to its high protein and vitamin value. It has demonstrated pharmacological effects that include antibacterial, anti-inflammatory and anti-fatigue activity. The nutrient-dense leaves can be eaten fresh, in salads, dried and in extracts. The objective of the work was to evaluate the anti-fatigue effect of moringa capsules in an animal model.
Methodology: It was evaluated anti-fatigue activity in male Swiss albino mice by forced swimming test with 5% of body weight as tail load (Brekhman test). The swimming time of the mouse without losing synchronism was the variable used to measure resistance until exhaustion. It was evaluated the administration of 1 or 2 moringa capsules per kilogram of body weight for 7 or 14 days. As positive controls, they were used 3 capsules of Codonopsis javanica and 250 mg/kg bow ascorbic acid.
Results: The exhaustive swimming time did not show significant differences between the groups treated with moringa capsules and the positive controls in the first and second evaluated periods, which indicated that the single dose of neither had an immediate anti-fatigue effect. Treatment with moringa capsules for 7 and 14 days prolonged the swimming time of the mice and reached a statistically significant increase at day 14. Conclusions: Treatment with a continuous dose of moringa capsules for 7 days has an anti-fatigue effect in mice subjected to effort.
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