Space-time distribution of pH fronts generated by a multiple array of electrode pairs
Keywords:
space-time distribution of pH fronts, electrolytic therapy for tumors, geometry of multiple pairs-electrodesAbstract
Introduction. The electrolytic ablation therapy uses for the cancer. The application of this therapy is simple, safe, effective and induces minima adverse events in the organism. The aim of this study is to simulate in silico pH fronts generated by a geometry of multiple pairs-electrodes inserted at 45º in an electrolytic medium that represent to the tumor.
Objective: To simulate in silico pH fronts generated by a multiple array of electrode pairs inserted at 45º in an electrolytic medium that represent to the tumor.
Methods. The two-dimensional Nernst-Planck equation is solved to describe the transport of four types of ions (hydrogen, hydroxyl, sodium and chlorine) in regions comprised by every pair of electrodes and away from of it.
Results. The pH fronts are circular around each electrode that forms the pair. The values of pH are smaller than 5 and bigger than 10 around each anode and cathode, respectively. These values of pH decrease in central regions comprised in the electrodes pair and away from of it.
Conclusions: It is concluded that pH fronts generated by multiple array of electrode pairs inserted to 45o in the study region adopt the shape of this electrode array. The simulations suggest that these pH fronts may explain why the destruction percentage of F3II mammary carcinoma is not higher 90 %, as predict the theory when the electric potential, electric field intensity and temperature are simulated, confirming that the electrochemical aspect is the possible antitumor action mechanism of electrolytic ablation therapy.
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