The association of Guillain-Barré syndrome with dengue fever was first described in Cuba
Keywords:
Dengue, Guillain-Barré syndrome, Cuba, outbreaks, viral diseasesAbstract
Introduction: Dengue fever is endemic in almost all tropical and subtropical countries. Guillain-Barré syndrome is one of the neurological complications that have been described.
Objective: To establish the first published articles associating dengue virus infection with the occurrence of Guillain-Barré syndrome.
Development: They were searched PubMed/Medline, Scielo and Google Scholar for articles relative to this association, published between 1950-2000. The search revealed that the first two articles were published in Cuba in 1981 and 1983 by professor Jose Rafael Estrada González in Revista Cubana de Higiene y Epidemiología. It was reported an increased incidence of Guillain-Barré syndrome during the first two large dengue outbreaks in Cuba (1977-1978 and 1981 respectively). The articles that immediately followed were case reports published in 1990 and 1993 from French Polynesia and French Guiana respectively.
Conclusions: The first documented evidence of the association between Guillain-Barré syndrome and dengue fever in the international scientific literature was published in Cuba by professor Estrada Gonzalez in 1981 and 1983.
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