Metal complexes with anticancer properties of acyl thioureas
Keywords:
acylthiourea, metal complexes, cytotoxicity, phosphine, microemulsionAbstract
Introduction: Metal ions and their complexes are vital in the human biological system. They are designed to target specific biological sites due to their wide range of geometries, coordination characteristics, and interaction with biological molecules. Many classical chemotherapeutic compounds have demonstrated not only antitumor activities but also unexpected antiviral action.
Objective: To obtain, characterize, determine the structure and evaluate the cytotoxic activity of complexes and ligands.
Methods: The reported acylthioureas and metal complexes were isolated and characterized by spectroscopic techniques, and the cytotoxic activity of ligands and complexes was evaluated and for one of the complexes, the experiment was carried out in three-dimensional cultures for tumor cells.
Results: N-alkyl- and N,N- dialkyl-N′-acylthioureas were synthesized to obtain metal complexes with different precursors, elemental analysis, molar conductivity, cyclic voltammetry, Insulin Resistance, Nuclear Magnetic Resonance (1H, 13C {31P{1H}), and X-ray diffraction. The cytotoxicity of the compounds was evaluated in lung, prostate and breast tumor cell lines.
Conclusions: Thirty-eight metal complexes of Pd(II), Pt(II), Ni(II), Cu(I), Ru(II) with acylthioureas were synthesized. The most common coordination for these compounds is through the sulfur oxygen atom of the thioureide group. The complexes show high cytotoxicity against the tumor cells tested, when compared to the IC50 reported for cisplatin and the trans-encapsulated complex [Ru(PPh3)2(N,N-dimethyl-N′-thiophenylthiourate-k2O,S)( bipy)]PF6 presented greater cytotoxicity, selectivity and is a promising strategy to increase its solubility, delivery and bioaccumulation in breast tumors.Downloads
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