COVID-19 and bile acids: new perspectives to consider

Authors

Keywords:

cholesterol, bile acids, COVID-19

Abstract

The lack of control of bile acids, signaling molecules with biological and pleotropic actions associated with the intestinal microbiota, the immune system and energy, lipid, glycemic and cholesterol metabolisms, amplifies the inflammatory response from the hepato-intestinal system to other organs involved with multiple failure and death. To describe their biomolecular evidence as possible metabolomic agents associated with complications of COVID-19, a systematic and critical review of what was published between 2000 and 2020 was carried out on their actions in supraphysiological conditions. These could constitute the theoretical basis that infer the damage of the cholangiolar epithelium by SARS-CoV-2, which favors the toxic action of bile acids, and allows the hypothesis of considering them as constituents of an axis that transverse this inflammatory process, as active participants in each of its stages, therefore, prognostic agents of this disease. Clinical studies are recommended for confirmation.

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Author Biographies

Felipe Neri Piñol Jiménez, Centro Nacional de Cirugía de Mínimo Acceso

Doctor en Ciencias, Doctor en Ciencias Médicas. Especialista de II Grado en Gastroenterología. Máster en Enfermedades Infecciosas. Profesor e Investigador Titular. Miembro Titular de la Sociedad Cubana de Gastroenterología. Miembro Internacional de la American College of Gastroenterology y Miembro Internacional de la American Society of Gastroenterology and Endoscopy. Centro Nacional de Cirugía de Mínimo Acceso. La Habana, Cuba.

Virginia Capo De Paz, Instituto de Medicina Tropical “Pedro Kouri”.

Doctora en Ciencias, Doctor en Ciencias Médicas. Especialista de II Grado en Anatomía Patológica. Profesor e Investigador Titular. Vicepresidenta de la Sociedad Cubana de Anatomía Patológica. Miembro numerario de la International Academy of Pathology. Instituto de Medicina Tropical “Pedro Kouri”. La Habana, Cuba

Bienvenido Gra Oramas, Instituto de Gastroenterología

Doctor en Ciencias Médicas. Especialista de II Grado en Anatomía Patológica. Profesor e Investigador Titular. Instituto de Gastroenterología. La Habana, Cuba.

Olga María Piera Rocillo, Facultad de Ciencias Médicas Calixto García. La Habana, Cuba.

Doctora en Ciencias Médicas. Especialista de II Grado en Anatomía Patológica. Profesor Consultante. Presidente del Consejo Científico. Facultad de Ciencias Médicas Calixto García. La Habana, Cuba.

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Published

2021-05-05

How to Cite

Piñol Jiménez, F. N., Capo De Paz, V., Gra Oramas, B., & Piera Rocillo, O. M. (2021). COVID-19 and bile acids: new perspectives to consider. Anales De La Academia De Ciencias De Cuba, 11(2), e968. Retrieved from https://revistaccuba.sld.cu/index.php/revacc/article/view/968

Issue

Vol. 11 No. 2 (2021): mayo-agosto

Section

Biomedical sciences

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